Electronic address: Synthase Kinase-3β (GSK-3β), a serine/threonine protein kinase, is an emerging therapeutic target in the treatment of human breast cancer. Lurie Comprehensive Cancer Center of Northwestern University, Olson Pavilion, 233 East Superior Street, Chicago, IL 60611, USA Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Searle Building 8-510, 320 East Superior Street, Chicago, IL 60611, USA. Lurie Comprehensive Cancer Center of Northwestern University, 2170 Campus Drive, Evanston, IL 60208, USA Chemistry of Life Processes Institute, Northwestern University, 2170 Campus Drive, Evanston, IL, 60208, USA Northwestern Medicine Developmental Therapeutics Institute, Robert H.

8 Center for Developmental Therapeutics, Robert H.

7 Department of Medicine, University of Wisconin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, Madison, WI 53705, USA.6 Chemistry of Life Processes Institute, Northwestern University, 2170 Campus Drive, Evanston, IL, 60208, USA.Lurie Comprehensive Cancer Center of Northwestern University, Olson Pavilion, 233 East Superior Street, Chicago, IL 60611, USA. 5 Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Galter Suite 3-150, 251 East Huron Street, Chicago, IL 60611, USA Northwestern Medicine Developmental Therapeutics Institute, Robert H.4 Institute of Genomics and Systems Biology, University of Chicago, 900 East 57th Street, KCBD 10100A, Chicago, IL 60637, USA.

3 Division of Oncology Research, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.

2 Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA.

Lurie Comprehensive Cancer Center of Northwestern University, 2170 Campus Drive, Evanston, IL 60208, USA Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Galter Suite 3-150, 251 East Huron Street, Chicago, IL 60611, USA Chemistry of Life Processes Institute, Northwestern University, 2170 Campus Drive, Evanston, IL, 60208, USA.

1 Center for Developmental Therapeutics, Robert H.

Chemistry of life processes institute